"Tumor cells undergo aerobic glycolysis to produce lactate even under normal oxygen concentration"
"Proliferating cells require large amounts of nucleotides, amino acids, lipids, glucose, glutamine (convert into lactate or alanine by the cells) to produce viable daughter cells
at a faster rate but less amount.
Aerobic glycolysis produce ATP
Mutated mitochondria inhibits Oxidative phosphorylation.
*Angiogenesis (Growth of blood vessels towards tumor cells) to support tumor cell high nutrition requirement. *Glutaminolysis- when glucose is used for anabolic procee then the cell switches to glutaminolysis for its energy source
Q1)Alternative source of energy in tumor cells? GLUTAMINOLYSIS! Q2) Tumor cells take more nutrition and oxygen by? ANGIOGENESIS!
Our Sincere thanks to professor Huaqian Wang