"Tumor cells undergo aerobic glycolysis to produce lactate even under normal oxygen concentration"
"Proliferating cells require large amounts of nucleotides, amino acids, lipids, glucose, glutamine (convert into lactate or alanine by the cells) to produce viable daughter cells
*Acetyl CoA is used to synthesize acyl chain *Citrate is used to synthesize lipids *Nitrogen is used to synthesise non-essential amino acids *Glutamine provides both Nitrogen and NADPH. *Disruption of ACL impairs tumor growth. *Inhibiting LDH activity impairs cell proliferation.
*ATP may never be limiting in cancer cells. *Oncogenic pathways drive cell autonomous nutrient uptake, program proliferative metabolism whereas tumor suppressor pathways is to prevent nutrient utilization for anabolic process.
at a faster rate but less amount.
Aerobic glycolysis produce ATP
Mutated mitochondria inhibits Oxidative phosphorylation.
Our Sincere thanks to professor Huaqian Wang