- A sodium gated voltage channel
- Plays a vital role in the transmission of pain signals
- Made up of 4 domains, each consisting of 6 segments named from s1-s6
- The difference in voltage between the exterior and interior of the neuron
- Nocireceptors cause the voltage inside the neuron to change
- Nav1.7 detects the change in voltage and becomes active
When Nav1.7 is active, the channel is open and sodium ions flow through the channel and into the neuron, increasing the membrane potential
Once the membrane potential reaches a certain point, the pain signal is sent from the neuron into the nervous system.